APSRR

Design · Procure · Build · Qualify · Comply · Operate

We build it. We maintain it. We support you through every inspection.

APSRR is a single turnkey partner for pharmaceutical facilities — one contract from the first drawing through regulatory licensing to the maintenance, requalification and spare support that keep the plant compliant for its entire life. No handoffs between contractors, vendors and consultants.

21 CFR 211 cGMP complianceISO 14644-1 particle countsEU GMP Annex 1 pressure and visualisationFDA facility registrationIEST-RP-CC034 filter integrityWHO TRS 961 thermal mapping 21 CFR 211 cGMP complianceISO 14644-1 particle countsEU GMP Annex 1 pressure and visualisationFDA facility registrationIEST-RP-CC034 filter integrityWHO TRS 961 thermal mapping

Everything, under one roof

One contract. Three commitments.

Wherever your facility is in its life, it falls under one of three things we're on the hook for.

01

Build

Design, procurement, construction and qualification — one site team from first drawing to signed certificate.

02

Maintain

Preventive and corrective maintenance, HVAC requalification and instrument calibration, scheduled before anything's due.

03

Support

Facility licensing, inspection readiness, spare parts and staffing — the backup that's still there after we leave site.

One point of accountability

One contract and one team, so nothing falls into the gap between contractors.

No vendor handoffs

The team that designs the room is the team that qualifies and maintains it.

Documentation from day one

As-builts, SOPs and certificates start at kickoff, not after a scramble at handover.

Still on call after handover

Maintenance, requalification and regulatory support don't end at the ribbon-cutting.

What we do

One contract, from first drawing to renewed license.

Design, procurement, construction, qualification, regulatory compliance and ongoing operations — run by one team so nothing gets lost at the handoffs.

Stage 01

We start with a requirement, not a floor plan.

A site walk, your process flow and target ISO class turn into a room-by-room specification and airflow scheme — the document everything downstream gets built against.

Facility & process design

Architecture, process flow and mass balance for the whole facility, not just classified rooms.

MEP & utility engineering

HVAC master plan, electrical, plumbing, purified water and gas systems, engineered together.

Cleanroom & airflow scheme

ISO classification, pressure cascade and air-change rates for every classified space.

Stage 02

One procurement team, so nothing gets stuck between vendors.

Process equipment, cleanroom systems and utility plant, sourced, vendor-qualified and scheduled against the build — not left for you to chase separately.

Process equipment

Vessels, filling lines, washers, depyrogenation tunnels and autoclaves, specified to your process.

Cleanroom & utility systems

Panels, AHUs, gas generation and purified water skids, matched to the design.

Vendor qualification & FAT

Supplier audits and factory acceptance testing coordinated before anything ships.

Filters, gauges and loggers can be ordered directly — for pricing and lead times.

Stage 03

Panels go up, systems come online, and the room gets its first balance.

Civil works, cleanroom fit-out, MEP and equipment installation — one site team, start to finish, to the approved drawings.

Civil & structural

Shell, slab and structural work for new-build or retrofit facilities.

Fit-out

Panels, ceilings, doors, coving and flooring installed to the approved drawings.

MEP & equipment installation

AHUs, ducting, utilities and process equipment set and connected.

Commissioning

Balancing, controls, leak checks and snag closure before qualification opens.

Wall and ceiling systems

Modular panels, walkable ceilings, flush view panels and coved corners throughout.

Doors and pass-throughs

Interlocked doors, dynamic and static pass boxes, airlocks and gowning sequences.

Flooring and finishes

Epoxy and vinyl systems, coving, sealed penetrations, cleanable surfaces.

Utilities and piping

Purified water loops, compressed air, dust extraction, drains and gas lines.

Filters, gauges and loggers for this stage — for pricing and lead times.

Stage 04

Every test, with the number it has to hit.

Room, HVAC and equipment qualification, process validation and instrument calibration — executed to written protocol and reported with raw data, calibration certificates and a signed summary within five working days.

HEPA filter integrity

≤ 0.01 % penetration
IEST-RP-CC034 · PAO scan

HVAC system qualification

DQ / IQ / OQ, AHU to terminal
ISO 14644-3 · ASHRAE 110

Airflow velocity and air changes

0.45 m/s ± 20 %
ISO 14644-3

Non-viable particle count

At rest and in operation
ISO 14644-1

Room pressure balancing

10–15 Pa cascade
ISO 14644-4 · EU GMP Annex 1

Temperature and humidity mapping

24 h minimum, loaded and empty
WHO TRS 961 Annex 9

Recovery and cleanup rate

100:1 decay in ≤ 20 min
ISO 14644-3

Airflow visualisation

Video record, both states
EU GMP Annex 1

Instrument calibration

Gauges, sensors and loggers
NIST-traceable

Equipment IQ/OQ

Installation & operational qualification
GAMP 5

Process validation

Three consecutive PPQ batches
FDA process validation guidance

Light, sound and UV intensity

Per facility URS
Site protocol

Stage 05

A facility that's built right still needs a license to run.

Facility registration, GMP licensing, SOPs and inspection readiness — built alongside the construction schedule so compliance isn't a scramble after handover.

Facility registration & licensing

FDA establishment registration, state board licensing and GMP certification support.

SOPs & documentation systems

Master SOPs, batch record design and electronic documentation systems, set up and trained on.

Inspection readiness

Gap assessments, mock audits and CAPA support ahead of a real regulatory inspection.

Stage 06

Certified, documented, and still on call after we leave.

As-builts and certificates at handover — plus maintenance, periodic qualification, spares and regulatory support, so the facility stays in spec and in compliance for the long run.

As-built documentation

Drawings, turnover packages and a room-by-room certificate set.

Staffing & training

Operator and GMP training programs to bring your team up to spec on day one.

Maintenance

Corrective service on cleanroom systems, HVAC and process equipment when something needs fixing.

Preventive maintenance

Scheduled PM programs for AHUs, terminal filters and utilities, so breakdowns are the exception.

Periodic qualifications

Scheduled requalification and internal audits, tracked and executed before they're due.

HVAC requalification

Periodic re-testing of AHUs and airflow systems to keep the original qualification current.

Calibrations

Scheduled recalibration of gauges, sensors and loggers, tracked against due dates.

Spare support

Critical spares for filters, gauges, loggers and process equipment, stocked and ready to ship.

Regulatory support

License renewals, change control filings and inspection support once the facility is operating.

Filters, gauges and loggers can be ordered any time — for pricing and lead times. For initial facility registration and licensing, see the stage.

Get in touch

Tell us what you're building, licensing or operating.

Room count and grades are enough for a first number on construction. For design, regulatory or ongoing support, a short scope note is enough to start.

Start to finish, one contract
Emailinfo@apsrr.com
Address5724 W Central Park Dr, Middletown, DE 19709

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